Objective: Bungur leaves have saponins, tannins, ellagitannin and flavonoids that could be function as antioxidant and antihyperglycemic. Bungur leaves also consumed in Indonesia people for their diabetes treatment for a long time. The aim of this research is to obtain the active compounds from plants that can acts as antioxidant and antihyperglycemic so that can be used in the alternative therapy of diabetes mellitus. Methods: Mice were made hyperglycemic using alloxan, except normal group. The study was carried out using 30 mice divided into 6 groups: normal group, negative group, positive group, and treated group with 3 dose variation from bungur leaves decoction and taken the data on day 0, 5th, and 19th. Results: The result in normal group, negative group (alloxan), positive group (glibenclamide), treatments group which given by doses 1.6 g/kgBW, 3.2 g/kgBW, 6.4 g/kgBW of MDA levels respectively 0.6993 nmol/mL ; 4.1953 nmol/mL ; 0.8462 nmol/mL ; 4.2873 nmol/mL ; 3.3700 nmol/mL ; 2.0670 nmol/mL while blood glucose levels on 19th day respectively 107.6 mg/dL ;149.2 mg/dL ; 104 mg/dL ; 93 mg/dL ; 109.6 mg/dL ; 104 mg/dL. MDA levels on 6.4 g/kgBW and the averages of MDA levels have different significantly with positive group, while blood glucose levels showed all treatments groups doses has no different significantly with positive group analyzed statistically. Conclusion: Decoction of bungur leaves have an effect to decrease MDA levels but not as well as glibenclamide while they have an effect to decrease blood glucose as well as glibenclamide.