Image of Curcumin Microencapsulation Using Chitosan–Ethyl Cellulose–Gms Mixture For Preservation Of Mucoadhesive Properties And Controlled Release Kinetic

Karya Ilmiah Dosen

Curcumin Microencapsulation Using Chitosan–Ethyl Cellulose–Gms Mixture For Preservation Of Mucoadhesive Properties And Controlled Release Kinetic



Objective: This research aimed to prepare curcumin microcapsules by the spray drying method and to evaluate their characteristics.
Methods: The microcapsules were prepared by the spray drying method. The generated microcapsules were evaluated for organoleptic, morphology, particle size, the percentage of curcumin and water content. Furthermore, the release of curcumin from the microcapsules was tested in vitro and compared to uncoated curcumin powder. In addition, the mucoadhesive properties of uncoated curcumin powder and curcumin microcapsules were also evaluated.
Results:The results showed that the microcapsules had spherical shape with particle size in the range of 100–1009 μm and water content of 9.34% (w/w) (FIII) and 8.09% (w/w) (FVI). The release of curcumin from its uncoated powder and the microcapsules FVI within 8 h were 8.87% and 26.32% (w/w), respectively. It was found that the mucoadhesive properties of microcapsules FVI were better than those of FIII and uncoated curcumin powder. Microcapsules FVI rendered the cumulative amount of curcumin remaining on the intestinal mucosa of 55% (w/w) within 3 h.
Conclusion: Accordingly, curcumin microcapsules generated by spray drying could be further formulated into various solid dosage forms for a better therapeutic effect.


Ketersediaan

EKIDUPT220132615/EKIDUPT220132Perpustakaan PusatT E R S E D I A

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Judul Seri
-
No. Panggil
615/EKIDUPT220132
Penerbit International Journal of Applied Pharmaceutics: India.,
Deskripsi Fisik
7 p.
Bahasa
English
ISBN/ISSN/NPM
0975-7058
Klasifikasi
615
Tipe Isi
text
Tipe Media
Textbook
Tipe Pembawa
-
Edisi
Vol. 14, No. 1
Subyek
Info Detil Spesifik
-
Pernyataan Tanggungjawab

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