xivrnABSTRACTrn(A) HOSANA LAURENCIA (2010210128)rn(B) ANTIPLASMODIAL ACTIVITIES OF EXTRACTS FROM FIVErnPLANTS ADMINISTERED ORALLY ON MICE INFECTED BYrnPlasmodium berghei strain ANKArn(C) xiv + 82 pages; 16 tables; 18 pictures; 18 attachmentsrn(D) Key words: Malaria, Plasmodium berghei, sirsak, guava, sambiloto, pulai,rninsulinrn(E) Malaria is currently an important public health problem in the world,rnincluding Indonesia. The failure of malaria eradication is caused byrnPlasmodium resistance to antimalarial drugs. Previous research at SeirnKepayang, Asahan, North Sumatra showed people use sirsak, guava,rnsambiloto, pulai and insulin to treat malaria. This study aimed to determinernin vivo antiplasmodial activities of ethanol leaf extracts of sirsak, guava,rnsambiloto, pulai and insulin on mice infected by Plasmodium berghei.rnAntiplasmodial activity testing was done by Primary Biological Assesmentrnmethod. Extracts were given orally at the dosage of 100 mg/kg BB, 200rnmg/kg BB, 400 mg/kg BB and 800 mg/kg BB for four days. Determinationrnof parasitemia can be done using both thick and thin blood smears,rnobtained results then analyzed using probit analysis. Ethanol leaf extractsrnof sirsak, guava, sambiloto, pulai and insulin have antiplasmodial activitiesrnagainst P. berghei with consecutive ED50 266,3177 mg/kg BB, 274,6908rnmg/kg BB, 63,0957 mg/kg BB, 121,9425 mg/kg BB, 474,2719 mg/kg BB.rnEthanol leaf extract of sambiloto is the most effective while insulin is thernmost uneffective.rn(F) Reference : 32 references (1989-2014)rn(G) Prof. Dr. Syamsudin, M.Biomed., Apt.; Drh. Rita Marleta Dewi, M.Kes.rn(H) 2015